Here are the annual death estimates in the U.S. for various causes:

1. Cigarette smoking: Smoking remains one of the leading preventable causes of death, contributing to about 480,000 deaths annually. This includes deaths from direct smoking and second-hand smoke exposure oai_citation:7,Facts About U.S. Deaths from Excessive Alcohol Use | Alcohol Use | CDC oai_citation:6,jamanetwork.com.
2. Alcohol: Excessive alcohol use is responsible for around 140,000 deaths per year, including both chronic conditions (like liver disease and cancer) and acute events (such as car accidents and alcohol poisoning) oai_citation:5,Facts About U.S. Deaths from Excessive Alcohol Use | Alcohol Use | CDC.
3. Guns: Gun-related deaths in the U.S. are estimated at about 48,000 per year, with the majority stemming from suicides and homicides oai_citation:4,jamanetwork.com.
4. Obesity: Obesity, along with related factors such as physical inactivity and poor diet, contributes to over 190,000 deaths each year, often through its connection to heart disease, diabetes, and other health complications oai_citation:3,Burden Calculated for Preventable Causes of Death | Harvard Medical School.
5. Heart disease: As the leading cause of death in the U.S., heart disease accounts for around 702,000 deaths annually, making up approximately 1 in every 5 deaths oai_citation:2,Heart Disease Facts | Heart Disease | CDC oai_citation:1,jamanetwork.com.

These numbers highlight the significant impact of lifestyle-related risk factors on public health in the U.S.