{"id":260146,"date":"2020-08-03T09:47:15","date_gmt":"2020-08-03T16:47:15","guid":{"rendered":"https:\/\/erickimphotography.com\/blog\/?p=260146"},"modified":"2020-08-03T09:51:38","modified_gmt":"2020-08-03T16:51:38","slug":"our-gut-is-our-first-brain","status":"publish","type":"post","link":"https:\/\/erickimphotography.com\/blog\/2020\/08\/03\/our-gut-is-our-first-brain\/","title":{"rendered":"Our Gut is Our First Brain"},"content":{"rendered":"\n<p>Interesting <a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7\">new peer-reviewed study from Nature (July 8th, 2020)<\/a> which suggests a deeper connection between the gut (what we moderns call the &#8216;microbiome&#8217;) and the brain.<\/p>\n\n\n\n<p>My theory:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Perhaps our gut (stomach) is our first brain&#8230; and far more intelligent than we give it credence.<\/p><\/blockquote>\n\n\n\n<p>The <a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7\">abstract<\/a> copy and pasted below:<\/p>\n\n\n\n<!--more-->\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1460\" height=\"1626\" data-attachment-id=\"260149\" data-permalink=\"https:\/\/erickimphotography.com\/blog\/2020\/08\/03\/our-gut-is-our-first-brain\/screen-shot-2020-08-03-at-12-48-16-pm\/\" data-orig-file=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?fit=1460%2C1626&amp;ssl=1\" data-orig-size=\"1460,1626\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screen-Shot-2020-08-03-at-12.48.16-PM\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?fit=1460%2C1626&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?resize=1460%2C1626&#038;ssl=1\" alt=\"\" class=\"wp-image-260149\" srcset=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?w=1460&amp;ssl=1 1460w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?resize=768%2C855&amp;ssl=1 768w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?resize=1379%2C1536&amp;ssl=1 1379w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-03-at-12.48.16-PM.jpg?resize=920%2C1025&amp;ssl=1 920w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><figcaption>An interesting direction to take our research onto the brain. My thought&#8211; first study the gut.<\/figcaption><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#article-info\"><em>Published:\u00c2\u00a0<time datetime=\"2020-07-08\">08 July 2020<\/time><\/em><\/a><\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7\">Microbiota modulate sympathetic neurons via a gut\u00e2\u20ac\u201cbrain circuit<\/a><\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li><a>Paul A. Muller,&nbsp;<\/a><\/li><li><a><\/a><a>Marc Schneeberger<\/a>,&nbsp;<\/li><li><a>Fanny Matheis<\/a>,&nbsp;<\/li><li><a>Putianqi Wang<\/a>,&nbsp;<\/li><li><a>Zachary Kerner<\/a>,&nbsp;<\/li><li><a>Anoj Ilanges<\/a>,&nbsp;<\/li><li><a>Kyle Pellegrino<\/a>,&nbsp;<\/li><li><a>Josefina del M\u00c3\u00a1rmol<\/a>,&nbsp;<\/li><li><a>Tiago B. R. Castro<\/a>,&nbsp;<\/li><li><a>Munehiro Furuichi<\/a>,&nbsp;<\/li><li><a>Matthew Perkins<\/a>,&nbsp;<\/li><li><a>Wenfei Han<\/a>,&nbsp;<\/li><li><a>Arka Rao<\/a>,&nbsp;<\/li><li><a>Amanda J. Picard<\/a>,&nbsp;<\/li><li><a>Justin R. Cross<\/a>,&nbsp;<\/li><li><a>Kenya Honda<\/a>,&nbsp;<\/li><li><a>Ivan de Araujo<\/a>&nbsp;&amp;&nbsp;<\/li><li><a>Daniel Mucida&nbsp;<\/a><\/li><\/ul>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/nature\"><em>Nature<\/em><\/a>\u00c2\u00a0<strong>volume\u00c2\u00a0583<\/strong>,\u00c2\u00a0pages 441\u00e2\u20ac\u201c446 (2020) <a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#citeas\">Cite this article<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"Abs1\">Abstract<\/h2>\n\n\n\n<p>Connections between the gut and brain monitor the intestinal tissue and its microbial and dietary content<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#ref-CR1\">1<\/a><\/sup>, regulating both physiological intestinal functions such as nutrient absorption and motility<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#ref-CR2\">2<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#ref-CR3\">3<\/a><\/sup>, and brain-wired feeding behaviour<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#ref-CR2\">2<\/a><\/sup>. It is therefore plausible that circuits exist to detect gut microorganisms and relay this information to areas of the central nervous system that, in turn, regulate gut physiology<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2474-7#ref-CR4\">4<\/a><\/sup>. Here we characterize the influence of the microbiota on enteric-associated neurons by combining gnotobiotic mouse models with transcriptomics, circuit-tracing methods and functional manipulations. We find that the gut microbiome modulates gut-extrinsic sympathetic neurons: microbiota depletion leads to increased expression of the neuronal transcription factor cFos, and colonization of germ-free mice with bacteria that produce short-chain fatty acids suppresses cFos expression in the gut sympathetic ganglia. Chemogenetic manipulations, translational profiling and anterograde tracing identify a subset of distal intestine-projecting vagal neurons that are positioned to have an afferent role in microbiota-mediated modulation of gut sympathetic neurons. Retrograde polysynaptic neuronal tracing from the intestinal wall identifies brainstem sensory nuclei that are activated during microbial depletion, as well as efferent sympathetic premotor glutamatergic neurons that regulate gastrointestinal transit. These results reveal microbiota-dependent control of gut-extrinsic sympathetic activation through a<strong> gut\u00e2\u20ac\u201cbrain circuit.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">ERIC KIM&#8217;s personal thoughts and take<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>There is a direct gut-brain connection.<\/p><\/blockquote>\n\n\n\n<p>Therefore, <strong><em>perhaps we should focus more on our &#8216;gut health&#8217; than our &#8216;<a href=\"https:\/\/erickimphotography.com\/blog\/2020\/07\/30\/how-to-improve-your-mental-health\/\">mental<\/a>&#8216; (brain) health<\/em><\/strong>. <\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/erickimphotography.com\/blog\/health\/\">Health is the Ultimate Wealth<\/a><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1600\" data-attachment-id=\"223460\" data-permalink=\"https:\/\/erickimphotography.com\/blog\/eric-kim-muscle-flex-00026-resized\/\" data-orig-file=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?fit=2560%2C1600&amp;ssl=1\" data-orig-size=\"2560,1600\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"side face selfie ERIC KIM muscle flex 00026-resized\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?fit=2560%2C1600&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?resize=2560%2C1600&#038;ssl=1\" alt=\"side face selfie ERIC KIM muscle flex 00026-resized\" class=\"wp-image-223460\" srcset=\"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?w=2560&amp;ssl=1 2560w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?resize=768%2C480&amp;ssl=1 768w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?resize=1536%2C960&amp;ssl=1 1536w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?resize=2048%2C1280&amp;ssl=1 2048w, https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/04\/ERIC-KIM-muscle-flex-00026-resized-scaled.jpg?resize=720%2C450&amp;ssl=1 720w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n<ul>\n<li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/08\/03\/diabetes-is-the-enemy\/\">Diabetes is the Enemy<\/a><\/li>\n<li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/06\/09\/how-to-quit-sugar\/\">How to Quit Sugar<\/a><\/li>\n<li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/07\/09\/how-to-improve-your-health\/\">How to Improve Your Health<\/a><\/li>\n<li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/07\/05\/biological-health-and-happiness\/\">Biological Health and Happiness<\/a><\/li>\n<\/ul>\n\n\n<figure class=\"wp-block-video wp-block-embed is-type-video is-provider-videopress\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"VideoPress Video Player\" aria-label='VideoPress Video Player' width='500' height='281' src='https:\/\/videopress.com\/embed\/SRVx6ETg?autoPlay=1&amp;loop=1&amp;muted=1&amp;persistVolume=0&amp;preloadContent=metadata&amp;hd=0&amp;cover=1' frameborder='0' allowfullscreen allow='clipboard-write'><\/iframe><script src='https:\/\/v0.wordpress.com\/js\/next\/videopress-iframe.js?m=1674852142'><\/script>\n<\/div><figcaption><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/07\/05\/biological-health-and-happiness\/\">Biological Health and Happiness<\/a><\/figcaption><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/07\/05\/health-is-king\/\">Health is King<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/04\/15\/health-is-wealth\/\">Health is Wealth<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/04\/15\/digestion\/\">Digestion<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/04\/12\/the-art-of-health\/\">The Art of Health<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/04\/12\/what-if-mood-originates-in-the-stomach-and-gut\/\">What if Mood Originates in the Stomach and Gut? Digestion Health<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/03\/07\/my-workout-fitness-powerlifting-philosophy-method-and-thoughts-beautify-your-own-body\/\">MY WORKOUT, FITNESS, POWERLIFTING PHILOSOPHY, METHOD, AND THOUGHTS: BEAUTIFY YOUR OWN BODY<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/03\/19\/how-to-grow-your-muscles\/\">How to Grow Your Muscles<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/03\/20\/overweight-vs-overfat\/\">Overweight vs Overfat<\/a><\/li><li><a href=\"https:\/\/erickimphotography.com\/blog\/2020\/03\/15\/how-to-add-muscle-and-subtract-fat-at-the-same-time\/\">How to Add Muscle and Subtract Fat at the Same Time<\/a><\/li><\/ul>\n\n\n<p>Become the best version of you<\/p>\n<ol>\n<li><a href=\"http:\/\/erickimphotography.com\/blog\/2018\/06\/05\/metabolism\/\">Metabolism<\/a><\/li>\n<li><a href=\"http:\/\/erickimphotography.com\/blog\/2017\/09\/05\/diet-health-and-fitness-for-photographers\/amp\/\">Diet, Health, and Fitness for Photographers<\/a><\/li>\n<li><a href=\"http:\/\/erickimphotography.com\/blog\/my-experiences-eating-only-one-meal-a-day\/\">My Experience Eating Only One Meal a Day<\/a><\/li>\n<li><a href=\"http:\/\/erickimphotography.com\/blog\/2017\/05\/01\/how-to-get-cut\/amp\/\">How to Get Cut.<\/a><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>Interesting new peer-reviewed study from Nature (July 8th, 2020) which suggests a deeper connection between the gut (what we moderns call the &#8216;microbiome&#8217;) and the brain. My theory: Perhaps our gut (stomach) is our first brain&#8230; and far more intelligent than we give it credence. The abstract copy and pasted below:<\/p>\n","protected":false},"author":1,"featured_media":259817,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-260146","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-posts"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/erickimphotography.com\/blog\/wp-content\/uploads\/2020\/08\/ERIC-KIM-rock-park-workout-00035-scaled.jpg?fit=2560%2C1600&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/posts\/260146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/comments?post=260146"}],"version-history":[{"count":10,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/posts\/260146\/revisions"}],"predecessor-version":[{"id":260157,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/posts\/260146\/revisions\/260157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/media\/259817"}],"wp:attachment":[{"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/media?parent=260146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/categories?post=260146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/erickimphotography.com\/blog\/wp-json\/wp\/v2\/tags?post=260146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}